To protect patient safety and to improve Pharma R&D efficiency, pharmaceutical developer need to anticipate potential drug-drug interactions early during development. The pharmaPendium DDI risk calculator uses a mechanistic static model identical to the one described in the 2020 FDA guide. 

See how the new Drug-Drug Interaction Risk Calculator works with this example use case that evaluates how to look at potential DDI risk for drugs that are substrates CYP2D6 – an important enzyme to evaluate as it metabolizes ~25% of clinical drugs.

The detailed DDIRC User Guide provides information on the approach and conventions used to make Drug-Drug Interaction calculations and provides step-by-step instructions for using the DDI Risk Calculator.

Also, take a look at the DDI risk calculator training videos to get started