Text searching

How to do a quick search in PharmaPendium (11 min)
With this video you will learn how to do a basic quick search and work with wildcards, exact phrase searches and Boolean operators. Thereby you will be able to retrieve critical hard-to-find data and valuable insight into, for example, reviewer responses

How to do an advanced search in PharmaPendium (9 min) slides
This video will explain you how to do an advanced text search in PharmaPendium. As an example, we explore how we can unlock critical insights on the use of Enteric coating in Gastrointestinal drugs.

Further processing text search results (12 min) / slides
Here we discuss how you can refine and process text search results to quickly zoom into the most relevant data. We show how to sort, filter, save and export our results and use the “Show drugs in” feature. We learn how to search within documents and approval packages, download documents and copy content.

Drug safety searching

Introduction to retrieving drug safety data (12 min) / slides
In this video we show how to retrieve extracted drug safety data in PharmaPendium. It covers content, taxonomies and a multiparametric live example around the question "What preclinical effects on QT prolongation have been observed in drugs that act on that same target?"

Using Boolean operators in drug safety searching (9 min) / slides
In this video we show how to retrieve drug safety data with high signal to noise using Boolean operators. We work with the example: "Show me all the approved antineoplastic drugs where Cardiac arrhythmia and changes in red blood cell numbers were observed in both rat and human"

FAERS searching

Analyzing FAERS data using the Summary Table/Graphical View (7 min)
In this video you will learn how to compare the post-market adverse event profiles of several drugs and/or drug classes, and create subsets of data, for example based on age-group or gender. We also show how to create a graphical representation of the data.

Customizing colour and ranges of Summary Table (5 min) / slides
With this video you will learn how to customize colours and ranges of the FAERS summary table view. This supports drug development and regulatory specialists to hightlight and zoom into the most relevant data quickly.

Finding post-market adverse events data using direct FAERS search (5 min) In this video you will learn how to find post market adverse event data on a drug irrespective of their role or based on a date or age-range of interest. We also discuss how to further filter, for example based on a co-medication of interest.

PK data searching

Retrieving high quality PK data by browsing for drugs (14 min)
In this video you will learn how you can retrieve high quality extracted PK data by browsing for drugs. As an example question we use "I am developing a new monoclonal antibody for Crohn's disease. What Cmax data is available on currently marketed drugs on Crohn’s disease?". This will help you to anticipate regulatory concerns, benchmark your drug and optimise dosing.

Retrieving high quality PK data by setting up a search in the PK data module (7 min)
In this video you will learn how you can retrieving high quality extracted PK data by starting a search in the PK data module. We show you how to set up a search in the PK data module, look at the PK parameter taxonomy and the PK data results view, show how to show/hide PK data columns, export PK data and explore source documents.

Metabolising enzymes and transporter (MET) data searching

Retrieving high quality extracted MET data by browsing for drugs (10 min) / slides
In this video you will learn how you can retrieve high quality extracted MET data by browsing for drugs. We touch upon extracted MET parameters and data sources, how to browse for drug by indication, the MET data results view, filtering and sorting MET data and explore source documents. This will help us to optimise experimental design, reduce development risk and improve patient safety.

Searching the Metabolising Enzymes and Transporter data with the MET module search page / slides
In this video you will learn how you can retrieve high quality extracted MET data through the MET module search window. We discuss how to set up a search in the MET module, explore the MET data results view, filter and sort MET data and export/process results.This will help you to decide what further preclinical and clinical studies to do, optimise submission and reduce post-market DDI safety risk.

Drug-drug interaction (DDI) risk calculator

High level introduction into Drug-drug interactions (4min). This video will provide a basic introduction in the cause, impact and mechanism of DDIs. This provides the foundation for the follow-up training video’s.

>Background introduction into PharmaPendium's DDI risk calculator (11 min) This video will provide a background introduction into PharmaPendium's DDI risk calculator. We discuss: mechanistic vs static modelling, victim and perpetrator drugs, FDA guidance and impact, and the workflow and predictive models of the DDI risk calculator. This provides a solid foundation for the live training videos.

DDI risk calculator training using your drug under development as victim drug (19 min) In this live training video we will show how to use PharmaPendium’s DDI risk calculator for predicting DDI risk for your drug under development as a victim. We discuss: What input is need, data and calculation transparency, user defined vs predicted fmE, exporting results, interpreting results and DDI result details

Efficacy searching

• How to find all indication where a specific endpoint was tested (4 min)
• How to find placebo effect data (4 min)
• How to find the sample sizes used in a clinical trials ( 6 min)

This video collection will teach you how to work with the efficacy module, helping you to retrieve essential data on endpoints, trial design and clinical results. These data help you to optimise your trial design, for example, the optimal number of patients, primary and second end-points, and appropriate population. Thereby driving efficiency and derisking development. Searching these data requires access to the efficacy module.

Further processing

How to share a search with other PharmaPendium users (8 min) / slides Sharing a search with other PharmaPendium users helps to effectively share critical insights within your organization and foster collaborations across departments. With this tutorial you will learn how to: Share a search (link/e-mail), create and modify a contact group, share a saved or recent search and manage shared searches.