• The DNA Analysis topic contains more information on evaluation of ESR1, PIK3CA, AKT, BRCA1, PALPB mutations to guide therapy
• The Immunotherapy topic now includes more information on evaluation of PD-L1 for treatment planning and tumor-infiltrating lymphocytes as well as new indication for immune checkpoint blockade in the neoadjuvant and advanced disease settings
• Reader-friendly design is further enhanced with new, full-color illustrations to show breast cancer incidence by age and ethnic group, recurrence over time, metastatic patterns, and survival over time.
• Provides details on normal breast histology, information to assist in processing breast specimens, and multitopic sections on diagnostic patterns, benign lesions, carcinomas, predictive and prognostic factors, stromal lesions, inflammatory lesions, lymphomas, and hereditary breast disease.
• Contains up-to-date information on HER2-low status, tumor infiltrating lymphocytes, and more
• Emphasizes the importance of correlation of pathologic lesions with findings on breast imaging and provides guidance on the interpretation of core needle biopsies

• 14 familial cancer syndrome topics updated in the Adrenal Gland and Paraganglia section including Adrenal Cortical Carcinoma, Pheochromocytoma/Paraganglioma, von Hippel-Lindau Syndrome, Carney Complex, Familial Paraganglioma Pheochromocytoma Syndrome, and McCune-Albright Syndrome

• Updates to images, text, and references throughout the book contain details related to the latest WHO Classification of Tumours: Digestive System Tumours, which include a change in how appendiceal neoplasms are classified, among other things
• Includes 10-15 new topics, including new information on targeted gene therapies, genetic variants of gastric and colonic carcinoma and the genetic syndromes that lead to GI tract cancers, COVID-19’s effects on the GI tract, iatrogenic (drug-induced) gastrointestinal diseases, and more
• Additional new content covers the changed approach to GI endocrine neoplasms and how to differentiate Grade 3 endocrine tumors from high-grade neuroendocrine carcinomas
• Provides invaluable information for busy residents who need easy access to details on neoplastic and nonneoplastic gastrointestinal diseases of the digestive tract to make specific diagnoses and prepare accurate, informative GI pathology reports
• Features revisited and refreshed content throughout, with new images, text, and references that reflect the latest research to ensure the section is as up to date as possible

The Cardiovascular update provides up-to-date, detailed topics covering the following:

• The expanded use of artificial intelligence (AI) in cardiovascular imaging
• Changes to the WHO’s classification and definition of pulmonary hypertension
• The latest CAD-RADS 2.0 classification
• The most recent WHO 2021 Classification of Thoracic Tumours
• New imaging guidelines for the management of acute and chronic chest pain and new transcatheter procedures
• Advances in PET and MR for inflammatory cardiomyopathies
• Advances in myocardial blood flow imaging with CT and MR
• CT and MR plaque analysis, including the use of CT-FFR (noninvasive/no-incision method, which generates 3D models of coronary arteries to identify potential blockages)
• COVID-related vascular complications, including post-COVID-19 myocarditis and systemic and pulmonary arterial thrombosis
• Novel dose-reduction techniques

The Cardiovascular update also features a range of additional updated content to reflect changes in diagnoses and disease management. These updates include coverage of the following:

• The new classification of arrhythmogenic cardiomyopathy, with emphasis on biventricular and left ventricular morphologies rather than only right ventricular morphologies
• Changes in the use of coronary and cardiac computed tomographic angiography (CTA), which is becoming a first-line test in many instances
• Advances in amyloidosis imaging and treatment response
• Numerous new transcatheter procedures, such as transcatheter mitral valve replacement and left atrial appendage occlusion, all of which undergo CTA with specific measurements prior to procedure
• Numerous new implants that need to be recognized on imaging
• New guidelines for imaging in the management of acute and chronic chest pain
• New concepts and updates in myocardial tissue mapping
• Updates to imaging of chronic thromboembolic pulmonary hypertension (CTEPH)
• Updates throughout based on the 2021 WHO Classification of Thoracic Tumours, including the updated WHO classification of pulmonary hypertension and definition of pulmonary hypertension
• Details on new imaging guidelines for the management of acute and chronic chest pain

The Spine updates delivers overviews, updates, and recommendations for evaluation of transitional spinal anatomy (spine enumeration) that have important and practical applications in routine imaging with downstream effects on spine intervention. Specific recommendations and updates include the following:

• Treatments for CSF-venous fistulas, including venous embolization and percutaneous fibrin glue placement, as well as updates with direct application for diagnosis of this pathology, such as photon-counting CT
• Updates to current biological and molecular characteristics of ependymal tumors
• Classification details of myelofibrosis and myelodysplastic syndromes; demyelinating disorders, including MOGAD and NMOSD; and expansion for classification of congenital spinal open and closed neural tube defects
• Full reordering of existing chapters with new knowledge, much regarding inflammatory and autoimmune disorders, as well as systemic manifestations of diseases
• Updated CSF leak disorder and root sleeve leak details; additional information on CSF-venous fistulas and the best methods of their detection; updates on treatments for CSF-venous fistulas, including venous embolization and percutaneous fibrin glue placement
• New details on updated areas of demyelinating disease related to better knowledge of MS, neuromyelitis optica spectrum disorder, and anti-MOG disorders          
• New and up-to-date genetic and disease information as well as updates on malignant nerve sheath tumor and paragangliomas
• Updates for spinal ependymomas, including myxopapillary and classical cellular spinal ependymoma

The Vascular update details the latest information across several ACR RADS criteria, which is the standardized framework for characterizing and reporting imaging findings. It also contains new material across several chapters from the LI-RADS, GB-RADS, and transplant criteria, which now include Doppler ultrasound with its noninvasive methodology rated highly for appropriate use:

• Since 2018, ongoing COVID-19 diagnoses have shown a higher incidence of venous thrombosis, which has led to increased use of Doppler extremity evaluations, particularly in hospitalized patients. DU2: Vascular contains Doppler ultrasound updates in several chapters.
• ACR Appropriateness Criteria, which include new “usually appropriate” ratings for diagnostic ultrasound (including Doppler ultrasound), are noted throughout the book’s techniques and diagnoses chapters. New Intersocietal Accreditation Commission (IAC) recommendations are also incorporated in several diagnosis chapters.
• Provides a wide range of anatomic detail, technical factors, and diagnostic criteria to guide accurate application of ultrasound throughout the body.
• Details new and evolving techniques such as the increasing use of microbubble imaging to enhance image resolution, distinguish vessels more clearly, and minimize noise and background signals
• Contains updated ACR Appropriateness Criteria regarding the new “highly appropriate” ratings

• Includes details from the WHO’s 5^th Edition Classification of Tumours of Haematopoietic and Lymphoid Tissues to ensure readers are up to date on new classification details, including new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates
• Also includes details from the International Consensus Classification of Hematolymphoid Neoplasms, which will provide a parallel body of knowledge to the WHO Classification with potential new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates
• Updated and new images and illustrations throughout
• A focus on updated technologies, newly recognized disorders, complications/features in blood and bone marrow, new targeted therapies, and the uptick in use of homeopathic remedies
• Molecular testing strategies based on specific neoplasms and specific differential diagnostic consideration

• This revision provides up-to-date coverage of a comprehensive spectrum of nonneoplastic and neoplastic conditions of the female genital tract. The contents are organized into five anatomic sections: vulva, vagina, uterus, ovary, and fallopian tube. In addition to usually encountered entities and conditions, the authors discuss uncommonly encountered ones as well, delivering crucial details to help pathologists reach a correct diagnosis. The contents are extremely thorough yet presented in a succinct, easy-to-access format that curates important information in a concise manner. The authors provide diagnostic pearls and have revised many of the book’s sections based on the WHO Classification of Tumours: Female Genital Tumours.
• Gyn’s contents reflect important molecular updates in endometrial carcinoma classifications based on the latest WHO classification, as well as updated classifications for squamous and glandular tumors for the lower genital tract, both in situ and invasive.

• The field of infectious disease is continually changing due to the emergence (e.g., COVID-19) and reemergence (e.g., Mpox) of infections capable of causing widespread morbidity and mortality, as well as the increasing number of infections coming from novel immunosuppressive therapies. This section has beens fully updated to address novel infections that have come about, along with lesser-known microorganisms that can markedly increase with new epidemics/pandemics. This section helps residents expand their knowledge and understanding of the field while providing a concise, accessible tool for complete, accurate surgical pathology reports.
• Features chapters on most to least common infections of the central nervous system, head and neck, skin/soft tissue, as well as on the pulmonary, cardiac, gastrointestinal, genitourinary, and gynecologic systems; also includes best approach for
• Details the increasing use of molecular diagnostics in infectious disease pathology
• Addresses the challenges in maximizing diagnostic yield while avoiding misinterpretation of results that could lead to false positives

• This section provides details on the most frequently encountered neoplastic entities in pediatric pathology and covers the rare but important edge cases as well. The book goes over each organ system in the body (including skin), as well as soft tissue, bones, and joints, with an overall focus on benign, borderline, and malignant infectious, congenital, and genetic conditions. Some chapters, such as those addressing adrenal tumors, have been combined and reorganized to better reflect the current grading systems. Content has been updated throughout, with revisions and additions to text, images, and references that eliminate out-of-date language, classification details, or diagnoses.

• Soft tissue pathology changes rapidly as new entities and variants are recognized and new molecular signatures for both new and existing entities become known. This section’s text, images, and references reflect the most current knowledge available.
• Includes updates across multiple chapters based on the most recent WHO Classification of Tumors: Soft Tissue and Bone Tumours (5th ed.)
• Updated contents and references cover new immunostains being used (mostly IHC surrogates for molecular testing)
• Provides comprehensive coverage of soft tissue pathology combined with accurate, concise clinicopathologic descriptions supported by thousands of high-quality photomicrographs, gross photographs, radiologic images, and medical illustrations
• Includes details throughout to help residents identify IHC and molecular genetics as they pertain to soft tissue pathology
• Features an image-rich layout with over 4,200 print and online images to make tumor identification and diagnosis faster and easier

• Text and imaging updates that tie common and very important but potentially uncommon current clinical issues to anatomy descriptions and examples as related to best practices for radiology reporting
• New and updated images and imaging techniques throughout
• Updated illustrations of the chest wall musculature with CT and MR examples
• Abdominal imaging best practices updates and an increasing emphasis on the application of body MR in the abdomen and pelvis
• Increased emphasis on the role of different modalities used for GU/GYN imaging, specifically retrograde urethrogram and MR for specific disease diagnosis
• Updated text, including:
• Anatomic basis for some thoracic developmental abnormalities
• Anatomic variants of systemic and pulmonary vasculature
• Additional details on the PI-RADS system and clinical implications of MR for prostate cancer
• Depicts common anatomic variants and covers common pathological processes
• Features representative pathologic examples to highlight the effect of disease on human anatomy

• All anatomy topics in the Basic and Intermediate sections of Head and Neck have been revised

• Updated tumor criteria in the 5th edition 2021 WHO Classification of Tumors: Central Nervous System Tumors, including advancements in molecular genomics and newly determined categories that identify tumor types/subtypes and facilitate differentiating subtypes
• An invaluable tool for busy trainees who need quickly accessible, detailed information about neoplastic and nonneoplastic pediatric diseases to make specific diagnoses and recommendations for further imaging or referral
• Pediatric Neuroradiology is the ideal collection for pediatric neuroradiologists and physicians in training who require a comprehensive resource for pediatric neuroimaging
• This section delivers a comprehensive collaboration of imaging and clinical and pathologic information

• Because pathologists require updates on the molecular panels used far more frequently for diagnosing cardiovascular disease, update includes new material from the currently expanding field of genetics on sudden cardiac death
• Includes details on the genetics that affect heart diseases—cardiomyopathy and aorta among them
• Covers amyloid treatment therapies that are now recommended
• Includes specifics on the reclassification of pulmonary arterial hypertension

• New reporting terminology (serous fluid and effusions) and updates to existing reporting terminologies
• Details on new immunohistochemical and molecular coverage, including new immunostains and genomic targets, as well as ancillary molecular test coverage in the thyroid section
• Image updates throughout that illustrate the expanded use and growth of fine-needle aspiration for small biopsies (FNA-B)
• The expanded use of FNA-B means small biopsy images will be added throughout, and many existing images will be updated to feature FNA-B
• Coverage of the new serous fluid classification system and the updated urinary cytology classification system, as well as new immunohistochemistry and molecular tests
• Updates on current and emerging reporting systems on pancreaticobiliary, salivary, breast, and soft tissue cytology

• Endocrine addresses characteristics of more than 150 diagnoses, and most entities are detailed with medical illustrations, micrographs, gross photographs, and other image types
• Contributions from renowned pathologists ensure that common/classic endocrine diagnoses, as well as newly recognized diseases and unusual cases, are well covered
• Endocrine offers a wealth of new information based on recently recognized and discovered endocrine diseases, as well as tumor types with important implications for patient care. This includes:

  • Recently described thyroid tumors now associated with DICER1 gene mutations
  • Correlation of newly characterized genetic abnormalities in endocrine tumors associated with responses to targeted therapies, as kinase fusion-related thyroid carcinomas and NTRK-rearranged thyroid carcinomas are now recognized as targetable tumors with correlation between genotype and tumor behavior and evolving resistance mechanisms against kinase inhibitors
• Newly recognized syndromes, such as multiple endocrine neoplasia type 4 and type 5, glucagon cell hyperplasia and neoplasia, and others

• While AJCC and WHO focus on tumors only, this section covers all topics, with emphasis on the diagnoses encountered in daily practice (such as infections and inflammatory/reactive issues)
• Includes many new diagnostic entities
• Limited or core needle biopsies that yield little tissue for analysis are increasingly employed by pathologists to identify head and neck diagnoses. This section includes all the diagnostic criteria, pertinent ancillary studies, and thorough, reciprocal differential diagnoses that general anatomic pathologists need to make diagnoses from these limited tissue samples.

• Lymphomas is a systematic, easy-to-use, and in-depth reference that covers benign and malignant lesions of lymph nodes, as well as extranodal lymphomas. The lymphomas are largely designated using the latest WHO classification terminology. Clinical and histologic features, results of relevant ancillary studies, and a differential diagnosis for each entry are provided with thousands of images that include gross pathology photographs, relevant clinical images, photomicrographs of histology and special stains, flow cytometry histograms, radiologic images, and detailed medical illustrations.

• All ExpertDDx topics are new or revised
• Updated nomenclature, particularly for tumors, with changes in WHO 2021 grading and WHO-specific nomenclature included
• Updated genetic information now available in Online Mendelian Inheritance in Man (OMIM) added throughout
• Topics deliver identification of the most common and important clinical and imaging challenges for brain diagnoses, as well as specific details on the most common, less common, and rare but important causes. Characteristic brain imaging studies are included along with key clinical and imaging features to help learners distinguish among possible etiologies

• All ExpertDDx topics are new or revised
• Updates to LI-RADS, Tanaka classifications

• All ExpertDDx topics are new or revised

• Updates to O-RADs

• All diagnosis topics are new or revised

  • Completely rewritten bleeding guidelines in all relevant chapters
  • Ablation coverage is separated out, and dedicated chapters have been created for liver/kidney/lung; coverage will include more advanced cases
  • Rewritten intratumor injection details for the Oncological Procedures section
  • Updated sheathed balloon stent delivery with hourglass configuration procedures

• All ExpertDDx topics are new or revised
• Updated nomenclature, particularly for tumors, with changes in WHO 2021 grading and WHO-specific nomenclature included
• Topics deliver identification of the most common and important clinical and imaging challenges for spine diagnoses, as well as specific details on the most common, less common, and rare but important causes. Characteristic spine imaging studies are included along with key clinical and imaging features to help learners distinguish among possible etiologies