What are Lists and how do I use them?

The Monographs A-Z feature lists all the 'All Populations' and 'Pediatric' drug monographs available in Clinical Pharmacology.

Follow these steps to find the monograph you are looking for:

1. From the Lists section, select ‘Monographs A-Z’. A horizontal bar displays across the top of the screen with buttons that represent numbers 0-9 and each letter of the alphabet.
2. Click the letter that represents the first letter of the drug name (for example, 'L'). The list of drug monographs displays. Icon links also display next to the monograph name, indicating whether an ‘All Populations’ and/or a ‘Pediatric' monograph is available.
3. Click an ‘All Populations’ or ‘Pediatric' monograph icon link to jump to the landing page for that monograph.
4. From the monograph landing page, you can do the following:

   • View the US drug names and global drug names of the drug selected.
   • Link to any section of the drug monograph.
   • Navigate between the 'All Populations' and 'Pediatric' monographs for a section (if available).
   • Begin a Drug Interaction Report, Adverse Reaction Report, or Clinical Comparison Report.
   • Link to MedCounselor Sheets for that monograph.
   • View a list of the available drug dosage forms.

The Beers Drug List includes potentially inappropriate medication use in older adults.The Beers criteria help health professionals determine therapies for older patients by listing three groups of medications:

1. Potentially Inappropriate: Potentially inappropriate medication use in older adults.
2. Potentially Inappropriate Due to Co-Morbid Conditions: Potentially inappropriate medication use in older adults due to drug-disease or drug-syndrome interactions that may exacerbate the disease or syndrome.
3. Use with Caution: Potentially inappropriate medications to be used with caution in older adults.

Select the group name in the list to find the drugs associated with it.

The List Combination Chemotherapy Regimens screen allows you to do the following:

• View a list of all indications (for example, disease states) and acronyms for which a combination chemotherapy regimen exists.
• Link to a specific combination chemotherapy regimen discussion.

You can search the list alphabetically by indication and then by acronym. Clicking on an acronym link opens a Combination Chemotherapy Regimen detail window.

Follow these steps to use the Combination Chemotherapy Regimens list:

1. From the Lists section, select 'Combo Chemotherapy Regimens'. The List screen displays.

   • A horizontal bar displays across the top of the screen with button links that represent numbers 0-9 and each letter of the alphabet.
   • Grayed-out links represent letters without Combination Chemotherapy Regimens.
2.  Click the first letter or number of the indication term/disease state you want to find (e.g. ‘M’, ‘L’ or ‘O’). A list appears that shows links for the number or letter selected.
3. Click an acronym link from the list.
4. A Combination Chemotherapy Regimen window opens and displays the treatment plan details for the selected indication and acronym. Chemotherapy Regimen components include the following:

   • Disease State: The combination regimen.
   • Chemotherapy Agents and Cycle Length: The dosage regimen.
   • Additional Instructions (if applicable).
   • Additional Note (if applicable).
   • References: Includes the Gold Standard Reference ID, reference text, and (if applicable) links to PubMed and ClinicalKey.

The Food and Drug Administration (FDA) has the authority to require a Risk Evaluation and Mitigation Strategy (REMS) from manufacturers to ensure that the benefits of a drug or biological product outweigh its risks.

The Products with REMS list allows you to search for products alphabetically by brand or generic name to view available REMS components for that product.

Follow the steps below to view a list of products for which the FDA has determined a REMS is required. Products that have been assigned a REMS but the documents are not yet available are also listed.

1. From the Lists section, select ‘Products with REMS’.
2. The List screen displays. A horizontal bar appears across the top of the screen with button links that represent numbers 0-9 and each letter of the alphabet.
3. Click the first letter of the name of the product (e.g. ‘L’, ‘M’, or ‘O’)
4. From the results that appear, click a product link (e.g. ‘Onsolis’).
5. A REMS Summary window opens and displays a list of all applicable REMS components for that product. REMS components can include the following:

   • Medication Guide
   • Communication Plan
   • ETASU (Elements To Assure Safe Use)
   • Implementation System
6. Click on a REMS Summary component link (if available) to view a PDF for the REMS component.

The Products with Medication Guides list features products for which the FDA has determined that a Medication Guide is required. You can search the list of products alphabetically. Each Medication Guide opens as a PDF file.

The Boxed Warnings monographs list allows you to easily find monographs that include at least one associated product for which the labeling has a boxed warning. Click on the ‘All Populations’ or ‘Pediatric’ monograph icon to view the Contraindication/Precaution section of the selected monograph, where you can view terms associated with Boxed Warnings.

The Interactions with Grapefruit Juice list features 'All Populations' and 'Pediatric' monographs that include an interaction with grapefruit juice.

The Confused Drug Names list features confused drug names identified by the Institute for Safe Medical Practices (ISMP). It includes look-alike and sound-alike drug pairs.

For ease in locating pairs, they are displayed twice in the list: under the correct drug name (followed by the confused name) and under the confused name (followed by the correct drug name). Clicking either name will open the monograph for the correct drug name. At the top of the monograph, a 'Confused Name' link appears. Click this to view the confused pairs associated with that monograph.

The Not Recommended for Splitting list features drug products that are not recommended for splitting (or breaking apart).

Examples of products flagged as not recommended for splitting include most extended-release tablets, delayed-release (enteric coated) tablets, capsules (powder, sprinkle, and liquid filled), suppositories, transdermal patches, finasteride, and ciprofloxacin.

The Package Requires Dilution list features drug packages that require either dilution or mixing before dispensing or administration.

The Do Not Crush List identifies oral dosage forms that should not be crushed, according to the Institute for Safe Medical Practices (ISMP).

High-Alert Medications are drugs identified by the Institute for Safe Medication Practices (ISMP) as bearing a heightened risk of causing significant patient harm when they are used in error. Although mistakes may or may not be more common with these drugs, the consequences are clearly more devastating to patients.

High-Alert Medications are drugs identified by the Institute for Safe Medication Practices (ISMP) as bearing a heightened risk of causing significant patient harm when they are used in error. Although mistakes may or may not be more common with these drugs, the consequences are clearly more devastating to patients.

A Narrow Therapeutic Index (NTI) Drug is a medication in which a small change in the dose or serum concentration may lead to serious adverse events or a therapeutic failure. A Narrow Therapeutic Index is defined as a < 2-fold difference between the median lethal and effective dose OR between the minimum toxic and minimum effective concentration. NTI drugs require careful titration and monitoring.

The Products by Manufacturer list features all drug manufacturers. Click on the manufacturer's name to display their contact information, company website link if applicable, and links to their products.