All relationships for a search term are represented in a ‘Sankey’ visual at the top of the results page. The search term is found in the middle of the visual, with ‘upstream relationships’ to the left of the search term and ‘downstream relationships’ to the right of the search term.

Upstream/downstream

Upstream relationships represent biological concepts that act on the search term (e.g., SIRT1 negatively regulates diabetes mellitus).

Downstream relationships represent biological concepts that are acted on by the search term (IL6 has a positive quantitative change because of diabetes mellitus)

Concept

Represent different biological entities (e.g., proteins, drugs, cell processes, etc) that have a relationship with the search term).

Effect

Can be positive, negative or unknown (in cases where the effect is not mentioned) or undefined (for relationship types that do not act positively or negatively)

Relation type

Represent different types of relationships concepts have with the search term.